Maitake beta-glucan MD-Fraction is the original patented product made to ISO standards in Japan. A phase I/II human trial, conducted by the Memorial Sloan–Kettering Cancer Center, showed maitake can stimulate the immune system of breast cancer patients.
Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity. 1,2 In this non-random case series, a combination of MD-fraction and whole maitake powder was inve ….
Reverse transcriptase polymerase chain reaction studies confirmed these findings; BAK-1 was one of most overexpressed gene, as observed by microarray assay. These findings confirm the apoptotic effect of maitake D fraction in breast cancer cells and further highlight the involvement of cytochrome c release to the cytoplasm.
The trial found a less than 10-20 percent improvement for leukemia, stomach cancer, and brain cancer patients. When maitake was taken in addition to chemotherapy, immune-competent cell activities were enhanced 1.2-1.4 times, compared with chemotherapy alone. Animal studies have supported the use of maitake MD-fraction for cancer.
What is maitake d fraction?
One maitake-specific beta-glucan that has been studied in recent years is its main active constituent known as “D-fraction”. Maitake’s D-fraction is comprised of unique protein-bound beta-glucans known as beta-1,3 glucan and beta-1,6 glucan (or a 3-branched ß-l,6-glucan with about 30% protein).
While reading we ran into the query “What are the health benefits of maitake D-fraction?”.
A 2013 study indicates that maitake D-Fraction could be useful in preventing and treating breast cancer. Researchers suggest that this mushroom can fight the growth and reproduction of cancerous cells.
Maitake’s D-fraction is comprised of unique protein-bound beta-glucans known as beta-1,3 glucan and beta-1,6 glucan (or a 3-branched ß-l,6-glucan with about 30% protein).
It is called MT-1 or simply ‘D-fraction’, an alkali-soluble, hot water extractable compound that contains approximately 30% protein, or a ratio of beta-glucan to protein of 7:3. It occurs in a concentration of 1.6 mg. Per gram of dried maitake mushrooms or .0016%.
Is maitake anti-diabetic?
Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake).
Does Maitake (Grifola frondosa) activate NK cells?
Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients. Immunomodulating activities of cultivated maitake medicinal mushroom Grifola frondosa (Dicks.:.